Analysis of a forward masking paradigm proposed to estimate cochlear compression using an auditory nerve model and signal detection theory
The healthy human auditory system has a large dynamic range. An “active mechanism”, presumably due to the electromotility of the outer hair cells in the cochlea, leads to level-dependent amplification of basilar membrane (BM) vibration and a compressive BM input/output function. Different methods for estimating this compressive function based on behavioural forward masking have been suggested. These methods are based on the assumption that BM processing can be isolated from the response of the overall system and that the forward masking onto the probe is different for on- and off-frequency maskers. In the present study, a computational model of the auditory nerve (AN) in combination with methods from signal detection theory was used to test these assumptions. The simulated AN response was quantified in terms of rate and synchrony for different AN fibre types. Contribution of different tonotopic regions to overall sensitivity to the stimuli were analysed. The results show that on- and off-frequency maskers produce similar forward masking onto the probe. The simulation results suggest that the estimate of compression based on the behavioural experiment cannot be derived from sensitivity at the level of the AN but requires additional contributions, consistent with physiological studies.
Encina-Llamas, G., Harte, J. M., Dau, T., Shinn-Cunningham, B., and Epp, B. (2019). “Investigating the effect of cochlear synaptopathy on envelope following responses using a model of the auditory nerve”, J. Assoc. Res. Otolaryngol., 20 (4),363–382. doi: 10.1007/s10162-019-00721-7.
Jepsen, M. L., and Dau, T. (2011). “Characterizing auditory processing and perception in individual listeners with sensorineural hearing loss”, J. Acoust. Soc. Am., 129 (1),262–281. doi: 10.1121/1.3518768.
Jones, P. R. (2016). “A tutorial on cue combination and Signal Detection Theory: Using changes in sensitivity to evaluate how observers integrate sensory information”, J. Math. Psychol., 73,117–139. doi: 10.1016/j.jmp.2016.04.006.
Liberman, M. C., and Dodds, L. W. (1984) “Single-neuron labeling and chronic cochlear pathology. III. Stereocilia damage and alterations of threshold tuning curves”, Hear. Res., 16(1),55–74. doi: 10.1016/0378-5955(84)90025-X.
Nelson,D. A., Schroder, A. C., and Wojtczak, M. (2001) “A new procedure for measuring peripheral compression in normal-hearing and hearing-impaired listeners”, J. Acoust. Soc. Am., 110(4),2045–2064, 2001. doi: 10.1121/1. 1404439.
Nelson, P. C., Smith, Z. M., and Young, E. D. (2009) “Wide-dynamic-range forward suppression in marmoset inferior colliculus neurons is generated centrally and accounts for perceptual masking”, J. Neurosci., 29(8),2553–2562. doi: 10.1523/ JNEUROSCI.5359-08.2009.
Ruggero, M. A., Rich, N. C., Recio, A., Narayan, S. S., and Robles, L. (1997) “Basilar-membrane responses to tones at the base of the chinchilla cochlea”, J. Acoust. Soc. Am., 101(4),2151–2163. doi: 10.1121/1.418265.
Yates, G. K., Winter, I. M., and Robertson, D. (1990) “Basilar membrane nonlinearity determines auditory nerve rate-intensity functions and cochlear dynamic range”, Hear. Res., 45(3),203 – 219. doi: 10.1016/0378-5955(90)90121-5.
Zilany, M. S. A., Bruce, I. C., and Carney, L. H. (2014) “Updated parameters and expanded simulation options for a model of the auditory periphery”, J. Acoust. Soc. Am., 135(1),283–286. doi: 10.1121/1.4837815.
Authors who publish with this journal agree to the following terms:
a. Authors retain copyright* and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
*From the 2017 issue onward. The Danavox Jubilee Foundation owns the copyright of all articles published in the 1969-2015 issues. However, authors are still allowed to share the work with an acknowledgement of the work's authorship and initial publication in this journal.