Clinical measures for investigating hidden hearing loss

  • Pernille Holtegaard Hearing Systems, Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark
  • Josefine J. Jensen Department of Nordic Studies and Linguistics, Copenhagen University, Copenhagen, Denmark
  • Bastian Epp Hearing Systems, Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark
Keywords: Hidden hearing loss, Auditory brainstem response, noise-induced neural degeneration, Speech recognition in noise, Tinnitus

Abstract

The present study compared clinical measures of auditory function in two listener groups prone to hidden hearing loss relative to a control group: a) listeners with tinnitus, and b) listeners with a history of noise-exposure. Auditory brainstem response (ABR) wave I, III and V were measured in response to a 4-kHz tone burst to quantify the level-growth of wave I and the amplitude difference between waves I-III and I-V. In addition, speech-in-noise performance using “Dantale I” and the Danish hearing in noise test (HINT) were assessed. The ABR wave-I level growth showed no difference between the tinnitus-, noise-exposed- and control group. The listeners with tinnitus had, however, significantly larger wave I-III differences indicating a gain at brainstem level. While the ABR results support that the wave I-III difference can be used as a physiological indicator of tinnitus, none of the applied audiological methods show signs of a noise-induced hidden hearing loss in the tested listener groups.

References

Bramhall, N.F., Konrad-Martin, D., McMillan, G.P., and Griest, S.E. (2017). “Auditory brainstem response altered in humans with noise exposure despite normal outer hair cell function,” Ear Hearing, 38, E1-E12. doi: 10.1097/AUD.0000000000000370.

Costalupes, J.A., Young, E.D., and Gibson, D.J. (1984). “Effects of continuous noise backgrounds on rate response auditory nerve fibers in cat,” J. Neurophysiol., 51, 1326-1344.

Elberling, C., Ludvigsen, C., and Lyregaard, P.E. (1989). “DANTALE – a new Danish speech material,” Scand. Audiol., 18, 169-175. doi:10.3109/01050398909070742.

Furman, A.C., Kujawa, S.G., and Liberman M.C. (2013). “Noise induced cochlear neuropathy is selective for fibers with low spontaneous rates,” J. Neurophysiol., 110, 577-586.

Hickox, A.E., and Liberman, M.C. (2014). “Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?” J. Neurophysiol., 111, 552-564.

Knipper, M., Dijk, P.V., Nunes, I., Rüttiger, L., and Zimmermann, U. (2013). “Advances in the neurobiology of hearing disorder: Recent developments regarding the basis of tinnitus and hyperacusis,” Prog. Neurobiol., 111, 17-33.

Kujawa, S.G., and Liberman, M.C. (2009). “Adding insult to injury: Cochlear nerve degeneration after “temporary” noise-induced hearing loss,” J. Neurosci., 29, 14077-14085.

Lawner, B.E., Harding, G.W., and Bohne, B.A. (1997). “Time course of nerve-fiber regeneration in the noise damaged mammalian cochlea,” Int. J. Dev. Neurosci., 15, 601-617.

Liberman, M.C. (1978). “Auditory-nerve response from cats raised in a low-noise chamber,” J. Acoust. Soc. Am., 63, 442-455.

Liberman, M.C., Epstein, M.J., Cleveland, S.S., Wang, H., and Maison, S.F. (2016). “Toward a differential diagnosis of hidden hearing loss in humans,” PLoS ONE, 11, e0162726. doi: 10.1371/journal.pone.0162726.

Nielsen, J.B., and Dau, T. (2009). “Development of a Danish speech intelligibility test,” Int. J. Audiol., 48, 729-741. doi: 10.1080/14992020903019312

Prendergast, G., Guest, H., Munro, K.J., Kluk, K., Leger, A., Hall, D.A., Heinz, G.A., and Plack, C.J. (2017). “Effects of noise exposure on young adults with normal audio-grams I: Electrophysiology,” Hear. Res., 344, 68-81. doi: 10.1016/j.heares.2016.10.028

Puel, J.L., Bobbin, R.P., and Fallon, M. (1988). “The active process is affected first by intense sound exposure,” Hear. Res., 37, 53-64.

Schaette, R., and McAlpine, D. (2011). “Tinnitus with a normal audiogram: Physiological evidence for hidden hearing loss and computational model,” Eur. J. Neurosci., 23, 3124-3138.

Stamper, G.C., and Johnson, T.A. (2015). “Letter to the Editor: Examination of potential sex influences in
Stamper, G.C & Johnson, T.A. (2015). Auditory function in normal-hearing, noise-exposed human ears, Ear Hearing, 36, 172-184,” Ear Hearing, 36, 738-740. doi: 10.1097/AUD.0000000000000228

Taberner, A.M., and Liberman, M.C. (2005). “Response properties of single auditory nerve fibers in the mouse,” J. Neurophysiol., 93, 557-569.

Zhao, F., and Stephens, D. (1996). “Hearing complaints of patients with King- Kopetzky Syndrome (obscure auditory dysfunction),” Br. J. Audiol., 30, 397-402.
Published
2018-02-06
How to Cite
Holtegaard, P., Jensen, J., & Epp, B. (2018). Clinical measures for investigating hidden hearing loss. Proceedings of the International Symposium on Auditory and Audiological Research, 6, 199-206. Retrieved from https://proceedings.isaar.eu/index.php/isaarproc/article/view/2017-24
Section
2017/4. Assessment of specific auditory functions and hearing ability