Relations between auditory brainstem response and threshold metrics in normal and impaired hearing listeners
Auditory brainstem responses (ABRs) offer a potential tool to diagnose auditory-nerve deficits in listeners with normal hearing thresholds as abnormalities in the amplitude of this population response may result from a loss in the number of auditory-nerve fibers contributing to this response. However, little is known about how cochlear gain loss interacts with auditory-nerve deficits to impact ABRs. We measured level-dependent changes in click-ABR wave-I and V in listeners with normal and elevated thresholds to study which measures are dominated by cochlear gain loss. ABR wave-V latency-vs-intensity functions correlated well to the distortion-product otoacoustic emission threshold and this relation was also observed for the slope of supra-threshold ABR wave-I level growth in listeners with thresholds above 20 dB SPL. ABR wave-I and wave-V growth were not related to each other, demanding caution when using ABR wave-V growth or level as a direct measure for auditory-nerve deficits.
Furman, A.C., Kujawa, S.G., and Liberman, M.C. (2013). “Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates,” J. Neurophys., 110, 577-586.
Gorga, M.P., Worthington, D.W., Reiland, J.K., Beauchaine, K.A., and Goldar, D.E. (1985). “Electrophysiological techniques in audiology and otology – some comparisons between auditory brain-stem response thresholds, latencies and the pure-tone audiogram,” Ear. Hearing, 6, 105-112.
Gu, J.W., Herrmann, B.S., Levine, R.A., and Melcher, J.R. (2012). “Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus,” J. Assoc. Res. Otolaryngol., 13, 819-833.
Hickox, A.E. and Liberman, M.C. (2014). “Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?” J. Neurophys., 111, 552-564.
Kujawa, S.G. and Liberman, M.C. (2009). “Adding insult to injury: cochlear nerve dege-neration after “temporary” noise-induced hearing loss,” J. Neurosci., 29, 14077-14085.
Kummer, P., Janssen T., and Arnold, W. (1998). “The level and growth behavior of the 2 f1−f2 distortion product otoacoustic emission and its relationship to auditory sensitivity in normal hearing and cochlear hearing loss,” J. Acoust. Soc. Am., 103, 3431-3444.
Long, G.R., Talmadge, C.L., and Lee, J. (2008). “Measuring distortion product otoacoustic emissions using continuously sweeping primaries,” J. Acoust. Soc. Am., 124, 1613-1626.
Mauermann, M. and Kollmeier, B. (2004). “Distortion product otoacoustic emission (DPOAE) input/output functions and the influence of the second DPOAE source,” J. Acoust. Soc. Am., 116, 2199-2212.
Melcher, J.R. and Kiang, N. (1996). “Generators of the brainstem auditory evoked potential in cat III: identified cell populations,” Hear. Res., 93, 52-71.
Neely, S.T., Johnson, T.A., and Gorga, M.P. (2005). “Distortion-product otoacoustic emission measured with continuously varying stimulus level,” J. Acoust. Soc. Am., 117, 1248-1259.
Schaette, R. and McAlpine, D. (2011). “Tinnitus with a normal audiogram: Physiological evidence for hidden hearing loss and computational model,” J. Neurosci., 31, 13452-13457.
Sergeyenko, Y., Lall, K., Liberman, M.C., and Kujawa, S.G. (2013). “Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline,” J. Neurosci., 33, 13686-13694.
Shera, C.A., Guinan, J.J.J., and Oxenham, A.J. (2010). “Otoacoustic estimation of coch-lear tuning: Validation in the chinchilla,” J. Assoc. Res. Otolaryngol., 11, 343-365.
Strelcyk, O., Christoforidis, D., and Dau, T. (2009). “Relation between derived-band auditory brainstem response latencies and behavioral frequency selectivity,” J. Acoust. Soc. Am. 124, 1878-1888.
Verhulst, S., Bharadwaj, H., Mehraei G., and Shinn-Cunningham, B.G. (2013). “Understanding hearing impairment through model predictions of brainstem responses,” Proc. Meetings Acoust., 19, 050182.
Verhulst, S., Bharadwaj, H., Mehraei, G., Shera, C.A., and Shinn-Cunningham, B.G. (2015). “Functional modeling of the human auditory brainstem response to broadband stimulation,” J. Acoust. Soc. Am., 138, 1637-1659.
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