TY - JOUR AU - Keshishzadeh, Sarineh AU - Verhulst, Sarah PY - 2020/04/14 Y2 - 2024/03/28 TI - From derived-band envelope-following responses to individualized models of near- and supra-threshold hearing deficits JF - Proceedings of the International Symposium on Auditory and Audiological Research JA - Proc. ISAAR VL - 7 IS - 0 SE - 2019/1. Auditory precision medicine DO - UR - https://proceedings.isaar.eu/index.php/isaarproc/article/view/2019-02 SP - 13-20 AB - <div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p>Auditory models which include frequency-dependent profiles of near and supra-threshold hearing deficits can aid the design of individualized hearing- aid algorithms. However, determining individual auditory-nerve (AN) fiber loss parameters is controversial as diagnostic metrics are presently based on auditory brainstem responses (ABRs) or envelope following responses (EFRs). These measures do not necessarily yield a frequency-specific quantification and might be affected by both outer-hair-cell and AN damage. We developed a derived-band EFR (DBEFR) metric to offer a frequency- specific assessment and complemented these with click-evoked otoacoustic emissions and audiometry. Cochlear-gain-loss profiles were derived from the latter measurements and inserted into individualized models, in which different synaptopathy profiles were introduced and DBEFRs simulated. Using a clustering technique, the best match between experimental and simulated synaptopathy profiles was determined and validated using the ABR data collected from the same listener. Results showed promise in offering a method to determine individualized sensorineural hearing-loss profile given a limited number of objective metrics.</p></div></div></div> ER -