Relations between auditory brainstem response and threshold metrics in normal and impaired hearing listeners
Auditory brainstem responses (ABRs) offer a potential tool to diagnose auditory-nerve deficits in listeners with normal hearing thresholds as abnormalities in the amplitude of this population response may result from a loss in the number of auditory-nerve fibers contributing to this response. However, little is known about how cochlear gain loss interacts with auditory-nerve deficits to impact ABRs. We measured level-dependent changes in click-ABR wave-I and V in listeners with normal and elevated thresholds to study which measures are dominated by cochlear gain loss. ABR wave-V latency-vs-intensity functions correlated well to the distortion-product otoacoustic emission threshold and this relation was also observed for the slope of supra-threshold ABR wave-I level growth in listeners with thresholds above 20 dB SPL. ABR wave-I and wave-V growth were not related to each other, demanding caution when using ABR wave-V growth or level as a direct measure for auditory-nerve deficits.
Bourien, J., Tang, Y., Batrel, C., Huet, A., Lenoir, M., Ladrech, S., Desmadryl, G., Nouvian, R., Puel, J.L., and Wang, J. (2014). “Contribution of auditory nerve fibres to compound action potential of the auditory nerve,” J. Neurophys., 12, 1025-1039.
Furman, A.C., Kujawa, S.G., and Liberman, M.C. (2013). “Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates,” J. Neurophys., 110, 577-586.
Gorga, M.P., Worthington, D.W., Reiland, J.K., Beauchaine, K.A., and Goldar, D.E. (1985). “Electrophysiological techniques in audiology and otology – some comparisons between auditory brain-stem response thresholds, latencies and the pure-tone audiogram,” Ear. Hearing, 6, 105-112.
Gu, J.W., Herrmann, B.S., Levine, R.A., and Melcher, J.R. (2012). “Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus,” J. Assoc. Res. Otolaryngol., 13, 819-833.
Hickox, A.E. and Liberman, M.C. (2014). “Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?” J. Neurophys., 111, 552-564.
Kujawa, S.G. and Liberman, M.C. (2009). “Adding insult to injury: cochlear nerve dege-neration after “temporary” noise-induced hearing loss,” J. Neurosci., 29, 14077-14085.
Kummer, P., Janssen T., and Arnold, W. (1998). “The level and growth behavior of the 2 f1−f2 distortion product otoacoustic emission and its relationship to auditory sensitivity in normal hearing and cochlear hearing loss,” J. Acoust. Soc. Am., 103, 3431-3444.
Long, G.R., Talmadge, C.L., and Lee, J. (2008). “Measuring distortion product otoacoustic emissions using continuously sweeping primaries,” J. Acoust. Soc. Am., 124, 1613-1626.
Mauermann, M. and Kollmeier, B. (2004). “Distortion product otoacoustic emission (DPOAE) input/output functions and the influence of the second DPOAE source,” J. Acoust. Soc. Am., 116, 2199-2212.
Melcher, J.R. and Kiang, N. (1996). “Generators of the brainstem auditory evoked potential in cat III: identified cell populations,” Hear. Res., 93, 52-71.
Neely, S.T., Johnson, T.A., and Gorga, M.P. (2005). “Distortion-product otoacoustic emission measured with continuously varying stimulus level,” J. Acoust. Soc. Am., 117, 1248-1259.
Schaette, R. and McAlpine, D. (2011). “Tinnitus with a normal audiogram: Physiological evidence for hidden hearing loss and computational model,” J. Neurosci., 31, 13452-13457.
Sergeyenko, Y., Lall, K., Liberman, M.C., and Kujawa, S.G. (2013). “Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline,” J. Neurosci., 33, 13686-13694.
Shera, C.A., Guinan, J.J.J., and Oxenham, A.J. (2010). “Otoacoustic estimation of coch-lear tuning: Validation in the chinchilla,” J. Assoc. Res. Otolaryngol., 11, 343-365.
Strelcyk, O., Christoforidis, D., and Dau, T. (2009). “Relation between derived-band auditory brainstem response latencies and behavioral frequency selectivity,” J. Acoust. Soc. Am. 124, 1878-1888.
Verhulst, S., Bharadwaj, H., Mehraei G., and Shinn-Cunningham, B.G. (2013). “Understanding hearing impairment through model predictions of brainstem responses,” Proc. Meetings Acoust., 19, 050182.
Verhulst, S., Bharadwaj, H., Mehraei, G., Shera, C.A., and Shinn-Cunningham, B.G. (2015). “Functional modeling of the human auditory brainstem response to broadband stimulation,” J. Acoust. Soc. Am., 138, 1637-1659.
How to Cite
Authors who publish with this journal agree to the following terms:
a. Authors retain copyright* and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
*From the 2017 issue onward. The Danavox Jubilee Foundation owns the copyright of all articles published in the 1969-2015 issues. However, authors are still allowed to share the work with an acknowledgement of the work's authorship and initial publication in this journal.